Mysimba Weight Loss Pill – Naltrexone and Bupropion

Mysimba Appetite SuppressantMysimba is the UK name for the American weight loss drug Contrave.

Although the drug was approved for use as a prescription medication in America in 2014, and is already in use in some European countries, it was not granted a UK medical licence until 2017.

At the time of this review, Mysimba was not available as a prescription weight loss aid, but its UK launch was expected to occur before the end of the year.

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What is Mysimba?

Mysimba is a weight loss medication that contains the drugs Naltrexone and Bupropion.

Naltrexone is normally used as a treatment for people who are addicted to opiate drugs or prone to alcohol abuse. Bupropion is an antidepressant. It is also sometimes prescribed to people who have stopped smoking and need help to battle the craving for cigarettes.

How Does Mysimba Help You To Lose Weight?

Mysimba is an appetite suppressant. Diet drugs of this nature curb hunger cravings and help make life easier for people who are trying to cope with eating less food.

When the drug is used in conjunction with diet and exercise, it should help create a calorie deficit that is great enough to cause the body to begin burning its stores of fat to obtain extra energy.

The appetite suppressing effect provided by Mysimba is achieved because of the drug’s ability to cause chemical changes in the brain that neutralize the desire for food. This is believed to be largely due to Bupropion’s ability to increase dopamine activity.

MySimba Ingredient Profile

One Mysimba tablet contains:

  • Naltrexone (90mg)
  • Bupropion (78mg)
Usage Instructions – The tablets have to be taken with water and swallowed whole. It is also recommended they be taken with food. The initial dose is one tablet per day. This is gradually increased until the maximum dose of two tablets, two times per day is achieved (week 4).

MySimba Customer Feedback?

At the time of our review Mysimba was yet to be launched in the UK, so no customer reviews were available. However, we found plenty of customer comments about Contrave (the same drug).

Some typical customer comments read:

“I only lost a few pounds during the first few weeks, but now I’m taking 4 pills a day I’m dropping around 3 pounds a week. Sometimes 4. The only side effect so far is I’m a little more constipated than normal but I can live with that.”
“Contrave works. I took it for 5 weeks and lost 18lbs. The big problem is there are a lot of side effects involved. I was getting a lot of headaches and started to get heart palpitations. Some days I felt sick and dizzy as well. My doctor said the side effects may pass, but they didn’t so I had to stop taking Contrave.”
“I used the pills in the right way and made the necessary changes to my diet. I never felt unduly hungry, so eating less was not a problem. The pills made me a little nauseous for the first few days, then it passed. I’ve already lost 15 pounds, so I am satisfied this medication works.”
“I felt really ill using these pills so after two weeks I decided enough is enough. I lost 11 pounds, so the pills obviously do their job, but I couldn’t stand feeling so sick and dizzy all the time and it was effecting my work.”

Who is MySimba Suitable For?

Mysimba is not suitable for people who are using some kinds of medication, including codeine, pimozide, and MAO inhibitors. It is also unsuitable for anyone who has certain medical conditions, such as diabetes, heart disease, and mood disorders.

Are There Any Potential Side Effects with MySimba

The combination of Naltrexone and Bupropion used in Mysimba is known to be capable of causing many side effects, including hot flushes, restlessness, muscle pain, liver damage, and suicidal thoughts. According to the European health watchdog, Prescribe, the slight weight loss the drug provides makes it “too risky for only modest weight loss“. Customer reviews suggest their evaluation is bang on the money.

Where Can I Buy Mysimba?

You can only buy Mysimba from a pharmacy if your doctor has issued you with a prescription.

Does Mysimba Work? (Summary)

MySimba weight loss pillLooking at customer reviews, and the damning evaluation provided by Prescrire, Mysimba appears to have the potential to help people to shed a few extra pounds, but it does not appear to be a particularly powerful drug and the potential for side effects is so high the bad points far outweigh the good.

The top weight loss supplements available are capable of providing far superior results and can do so without presenting the same risk of side effects. Bearing this in mind it is hard to understand why anyone would want to risk using a weight loss drug that is as controversial as Mysimba.

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Belviq – Lorcaserin Tablets, How They Work, Side Effects, How To Obtain

Belviq StockistsBELVIQ is the brand name used for the weight loss drug Lorcaserin. [UPDATED FOR AUGUST 2018]

The drug was created in America by Arena Pharmaceuticals, has somewhat of a chequered past, and is not deemed an acceptable weight loss option in many countries of the world.

Arena Pharmaceuticals first submitted BELVIQ to the Food and Drug Administration (FDA) for approval in December 2009.

The following September the FDA refused to approve the drug due to concerns about its safety and efficiency. The fact that some studies suggested the drug had caused tumours in rats was particularly damning.

In May 2012, after additional studies had been conducted, the FDA advisory panel voted in favour of making BELVIQ available as a prescription only weight loss aid and a press release was made public the following month.

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Attempts were made to distribute the drug in Europe as well, but the European Medicines Agency took a look at the information Arena Pharmaceuticals had provided, were worried about the possibility of tumours and that the drug may be damaging to the heart valve.

When the Committee for Medicinal Products for Human Use contacted Arena Pharmaceuticals with a list of questions about BELVIQ the company withdrew its application. BELVIQ cannot be legally distributed in any European countries and this is a fact that is unlikely to change in the future.

Belviq Pills

How BELVIQ Works

BELVIQ is an appetite suppressant.

Appetite suppressants are designed to help people to eat less food without having to live with the distraction of hunger pangs.

Feelings of hunger are one of the biggest hurdles dieters have to face and can often be the deciding factor that causes dieters to forget their good intentions and break their diet. Use of appetite suppressing drugs or supplements may give dieters the extra support they need and ensure weight loss success.

Appetite suppression can be achieved in a number of ways. BELVIQ works by activating receptors in the brain and this ultimately leads to a feeling of satiety that allows the user to feel satisfied with less food.

A reduction in eating levels results in a decrease in calories and, if the level of calories consumed per day drops to a level that is less than the body requires, fat will need to be mobilised and burned to provide extra energy.

Usage Guidelines

BELVIQ is only available as a 10mg capsule and the correct dose is one capsule, twice per day, which can be taken with food or without food. It is also very important that the drug be used as part of an overall weight management program that includes a healthy diet and regular exercise. This one of the stipulations the FDA put in place when they granted their approval, and patients who fail to lose 5% of their bodyweight after three months will not receive any further prescriptions.


The FDA have issued strict guidelines doctors must use to decide a patient’s eligibility.

Patients must have BMI of 27 or more and suffer from a weight-related health problem, such as high cholesterol or diabetes. When a patients BMI reaches 30 or higher doctors are permitted to write a prescription even in cases where no health problems are apparent.

However, doctors can also refuse to issue a prescription if the patient’s medical history suggests BELVIQ may not be a safe option.

As far as pregnancy category goes, the FDA considers BELVIQ to be an “X”. Drugs that are placed in this category can pose a risk to the fetus, so BELVIQ is not suitable from women who are pregnant. It may also be unsuitable for people who have heart problems, sickle cell anaemia, leukaemia, kidney problems, liver disease, or certain other medical conditions.

Unfavorable Interactions

BELVIQ is not suitable for use alongside some medications including lithium, St. John’s Wort, and monamine oxidasae inhibitors.

Potential for Side Effects

People who suffer from diabetes are apparently more susceptible to certain common side effects. These include:

  • Headaches
  • Fatigue
  • Cough
  • Hypoglycemia
  • Back pain

Other possible side effects dieters may encounter are:

  • Nausea
  • Dizziness
  • Dry mouth
  • Reduction in blood sugar
  • Hallucinations
  • Painful erection
  • Slowed hart beat
  • Problems focussing
  • Depression
  • Thoughts of suicide

Other Considerations

BELVIQ is listed in Schedule 5 of the Controlled Substances Act because it is a drug that could be abused and used for recreational use. There is also a danger of addiction, so BELVIQ may not be suitable for anyone who has a history of recreational drug use and/or dependency issues.

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